Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
Identifieur interne : 003695 ( Main/Exploration ); précédent : 003694; suivant : 003696Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
Auteurs : Petter S. Woll [Royaume-Uni] ; Una Kj Llquist [Suède] ; Onima Chowdhury [Royaume-Uni] ; Helen Doolittle [Royaume-Uni] ; David C. Wedge [Royaume-Uni] ; Supat Thongjuea [Royaume-Uni] ; Rikard Erlandsson [Suède] ; Mtakai Ngara [Suède] ; Kristina Anderson [Norvège] ; Qiaolin Deng [Suède] ; Adam J. Mead [Royaume-Uni] ; Laura Stenson [Royaume-Uni] ; Alice Giustacchini [Royaume-Uni] ; Sara Duarte [Royaume-Uni] ; Eleni Giannoulatou [Royaume-Uni] ; Stephen Taylor [Royaume-Uni] ; Mohsen Karimi [Suède] ; Christian Scharenberg [Suède] ; Teresa Mortera-Blanco [Suède] ; Iain C. Macaulay [Royaume-Uni] ; Sally-Ann Clark [Royaume-Uni] ; Ingunn Dybedal [Norvège] ; Dag Josefsen [Norvège] ; Pierre Fenaux [France] ; Peter Hokland [Danemark] ; Mette S. Holm [Danemark] ; Mario Cazzola [Italie] ; Luca Malcovati [Italie] ; Sudhir Tauro [Royaume-Uni] ; David Bowen [Royaume-Uni] ; Jacqueline Boultwood [Royaume-Uni] ; Andrea Pellagatti [Royaume-Uni] ; John E. Pimanda [Australie] ; Ashwin Unnikrishnan [Australie] ; Paresh Vyas [Royaume-Uni] ; Gudrun Göhring [Allemagne] ; Brigitte Schlegelberger [Allemagne] ; Magnus Tobiasson [Suède] ; Gunnar Kvalheim [Norvège] ; Stefan N. Constantinescu [Belgique] ; Claus Nerlov [Royaume-Uni] ; Lars Nilsson [Suède] ; Peter J. Campbell [Royaume-Uni] ; Rickard Sandberg [Suède] ; Elli Papaemmanuil [Royaume-Uni] ; Eva Hellström-Lindberg [Suède] ; Sten Linnarsson [Suède] ; Sten Eirik W. Jacobsen [Suède]Source :
- Cancer cell [ 1878-3686 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Animaux, Antigènes CD (biosynthèse), Antigènes CD (immunologie), Cellules souches tumorales (anatomopathologie), Cellules souches tumorales (immunologie), Cellules souches tumorales (physiologie), Chromosomes humains de la paire 5, Cytométrie en flux, Délétion de segment de chromosome, Humains, Hétérogreffes, Mutation, Pronostic, Prédisposition génétique à une maladie, Souris, Souris de lignée NOD, Syndromes myélodysplasiques (anatomopathologie), Syndromes myélodysplasiques (génétique), Syndromes myélodysplasiques (immunologie).
- MESH :
- anatomopathologie : Cellules souches tumorales, Syndromes myélodysplasiques.
- biosynthèse : Antigènes CD.
- génétique : Syndromes myélodysplasiques.
- immunologie : Antigènes CD, Cellules souches tumorales, Syndromes myélodysplasiques.
- physiologie : Cellules souches tumorales.
- Analyse de profil d'expression de gènes, Animaux, Chromosomes humains de la paire 5, Cytométrie en flux, Délétion de segment de chromosome, Humains, Hétérogreffes, Mutation, Pronostic, Prédisposition génétique à une maladie, Souris, Souris de lignée NOD.
English descriptors
- KwdEn :
- Animals, Antigens, CD (biosynthesis), Antigens, CD (immunology), Chromosome Deletion, Chromosomes, Human, Pair 5, Flow Cytometry, Gene Expression Profiling, Genetic Predisposition to Disease, Heterografts, Humans, Mice, Mice, Inbred NOD, Mutation, Myelodysplastic Syndromes (genetics), Myelodysplastic Syndromes (immunology), Myelodysplastic Syndromes (pathology), Neoplastic Stem Cells (immunology), Neoplastic Stem Cells (pathology), Neoplastic Stem Cells (physiology), Prognosis.
- MESH :
- chemical , biosynthesis : Antigens, CD.
- chemical , immunology : Antigens, CD.
- genetics : Myelodysplastic Syndromes.
- immunology : Myelodysplastic Syndromes, Neoplastic Stem Cells.
- pathology : Myelodysplastic Syndromes, Neoplastic Stem Cells.
- physiology : Neoplastic Stem Cells.
- Animals, Chromosome Deletion, Chromosomes, Human, Pair 5, Flow Cytometry, Gene Expression Profiling, Genetic Predisposition to Disease, Heterografts, Humans, Mice, Mice, Inbred NOD, Mutation, Prognosis.
Abstract
Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.
DOI: 10.1016/j.ccr.2014.03.036
PubMed: 24835589
Affiliations:
- Allemagne, Australie, Belgique, Danemark, France, Italie, Norvège, Royaume-Uni, Suède
- Angleterre, Basse-Saxe, Nouvelle-Galles du Sud, Oxfordshire, Vienne (Autriche), Østlandet
- Hanovre, Louvain-la-Neuve, Oslo, Oxford, Sydney, Vienne (Autriche)
- Université catholique de Louvain, Université d'Oxford
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Le document en format XML
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Mead</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Stenson, Laura" sort="Stenson, Laura" uniqKey="Stenson L" first="Laura" last="Stenson">Laura Stenson</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Giustacchini, Alice" sort="Giustacchini, Alice" uniqKey="Giustacchini A" first="Alice" last="Giustacchini">Alice Giustacchini</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Duarte, Sara" sort="Duarte, Sara" uniqKey="Duarte S" first="Sara" last="Duarte">Sara Duarte</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Giannoulatou, Eleni" sort="Giannoulatou, Eleni" uniqKey="Giannoulatou E" first="Eleni" last="Giannoulatou">Eleni Giannoulatou</name><affiliation wicri:level="4"><nlm:affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Taylor, Stephen" sort="Taylor, Stephen" uniqKey="Taylor S" first="Stephen" last="Taylor">Stephen Taylor</name><affiliation wicri:level="4"><nlm:affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Karimi, Mohsen" sort="Karimi, Mohsen" uniqKey="Karimi M" first="Mohsen" last="Karimi">Mohsen Karimi</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Scharenberg, Christian" sort="Scharenberg, Christian" uniqKey="Scharenberg C" first="Christian" last="Scharenberg">Christian Scharenberg</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Mortera Blanco, Teresa" sort="Mortera Blanco, Teresa" uniqKey="Mortera Blanco T" first="Teresa" last="Mortera-Blanco">Teresa Mortera-Blanco</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Macaulay, Iain C" sort="Macaulay, Iain C" uniqKey="Macaulay I" first="Iain C" last="Macaulay">Iain C. Macaulay</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Clark, Sally Ann" sort="Clark, Sally Ann" uniqKey="Clark S" first="Sally-Ann" last="Clark">Sally-Ann Clark</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Dybedal, Ingunn" sort="Dybedal, Ingunn" uniqKey="Dybedal I" first="Ingunn" last="Dybedal">Ingunn Dybedal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Oslo University Hospital, Rikshospitalet, 0130 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Hematology, Oslo University Hospital, Rikshospitalet, 0130 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Josefsen, Dag" sort="Josefsen, Dag" uniqKey="Josefsen D" first="Dag" last="Josefsen">Dag Josefsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Fenaux, Pierre" sort="Fenaux, Pierre" uniqKey="Fenaux P" first="Pierre" last="Fenaux">Pierre Fenaux</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (AP-HP), Service d'hématologie clinique, 93000 Bobigny, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (AP-HP), Service d'hématologie clinique, 93000 Bobigny</wicri:regionArea><wicri:noRegion>93000 Bobigny</wicri:noRegion><wicri:noRegion>93000 Bobigny</wicri:noRegion></affiliation></author><author><name sortKey="Hokland, Peter" sort="Hokland, Peter" uniqKey="Hokland P" first="Peter" last="Hokland">Peter Hokland</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Aarhus University Hospital, 8000 Aarhus</wicri:regionArea><wicri:noRegion>8000 Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Holm, Mette S" sort="Holm, Mette S" uniqKey="Holm M" first="Mette S" last="Holm">Mette S. Holm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Aarhus University Hospital, 8000 Aarhus</wicri:regionArea><wicri:noRegion>8000 Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Cazzola, Mario" sort="Cazzola, Mario" uniqKey="Cazzola M" first="Mario" last="Cazzola">Mario Cazzola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Malcovati, Luca" sort="Malcovati, Luca" uniqKey="Malcovati L" first="Luca" last="Malcovati">Luca Malcovati</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Tauro, Sudhir" sort="Tauro, Sudhir" uniqKey="Tauro S" first="Sudhir" last="Tauro">Sudhir Tauro</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Sciences, University of Dundee, Dundee DD1 9SY, Scotland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Medical Sciences, University of Dundee, Dundee DD1 9SY, Scotland</wicri:regionArea><wicri:noRegion>Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Bowen, David" sort="Bowen, David" uniqKey="Bowen D" first="David" last="Bowen">David Bowen</name><affiliation wicri:level="1"><nlm:affiliation>St. James Institute of Oncology, St. James Hospital, Leeds LS9 7TF, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St. James Institute of Oncology, St. James Hospital, Leeds LS9 7TF</wicri:regionArea><wicri:noRegion>Leeds LS9 7TF</wicri:noRegion></affiliation></author><author><name sortKey="Boultwood, Jacqueline" sort="Boultwood, Jacqueline" uniqKey="Boultwood J" first="Jacqueline" last="Boultwood">Jacqueline Boultwood</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Pellagatti, Andrea" sort="Pellagatti, Andrea" uniqKey="Pellagatti A" first="Andrea" last="Pellagatti">Andrea Pellagatti</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Pimanda, John E" sort="Pimanda, John E" uniqKey="Pimanda J" first="John E" last="Pimanda">John E. Pimanda</name><affiliation wicri:level="1"><nlm:affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Unnikrishnan, Ashwin" sort="Unnikrishnan, Ashwin" uniqKey="Unnikrishnan A" first="Ashwin" last="Unnikrishnan">Ashwin Unnikrishnan</name><affiliation wicri:level="1"><nlm:affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Vyas, Paresh" sort="Vyas, Paresh" uniqKey="Vyas P" first="Paresh" last="Vyas">Paresh Vyas</name><affiliation wicri:level="4"><nlm:affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Oxford University Hospital, NHS Trust, Oxford OX3 9DU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Oxford University Hospital, NHS Trust, Oxford OX3 9DU</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Gohring, Gudrun" sort="Gohring, Gudrun" uniqKey="Gohring G" first="Gudrun" last="Göhring">Gudrun Göhring</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Schlegelberger, Brigitte" sort="Schlegelberger, Brigitte" uniqKey="Schlegelberger B" first="Brigitte" last="Schlegelberger">Brigitte Schlegelberger</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Tobiasson, Magnus" sort="Tobiasson, Magnus" uniqKey="Tobiasson M" first="Magnus" last="Tobiasson">Magnus Tobiasson</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Kvalheim, Gunnar" sort="Kvalheim, Gunnar" uniqKey="Kvalheim G" first="Gunnar" last="Kvalheim">Gunnar Kvalheim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Constantinescu, Stefan N" sort="Constantinescu, Stefan N" uniqKey="Constantinescu S" first="Stefan N" last="Constantinescu">Stefan N. Constantinescu</name><affiliation wicri:level="4"><nlm:affiliation>Ludwig Institute for Cancer Research and de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ludwig Institute for Cancer Research and de Duve Institute, Université Catholique de Louvain, 1200 Brussels</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement><settlement type="city">Louvain-la-Neuve</settlement></placeName><orgName type="university">Université catholique de Louvain</orgName></affiliation></author><author><name sortKey="Nerlov, Claus" sort="Nerlov, Claus" uniqKey="Nerlov C" first="Claus" last="Nerlov">Claus Nerlov</name><affiliation wicri:level="4"><nlm:affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Nilsson, Lars" sort="Nilsson, Lars" uniqKey="Nilsson L" first="Lars" last="Nilsson">Lars Nilsson</name><affiliation wicri:level="1"><nlm:affiliation>Skåne University Hospital, Lund 221 00, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Skåne University Hospital, Lund 221 00</wicri:regionArea><wicri:noRegion>Lund 221 00</wicri:noRegion></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge</wicri:regionArea><wicri:noRegion>CB10 1SA Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Sandberg, Rickard" sort="Sandberg, Rickard" uniqKey="Sandberg R" first="Rickard" last="Sandberg">Rickard Sandberg</name><affiliation wicri:level="1"><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm</wicri:regionArea><wicri:noRegion>171 77 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge</wicri:regionArea><wicri:noRegion>CB10 1SA Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellström-Lindberg">Eva Hellström-Lindberg</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Linnarsson, Sten" sort="Linnarsson, Sten" uniqKey="Linnarsson S" first="Sten" last="Linnarsson">Sten Linnarsson</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm</wicri:regionArea><wicri:noRegion>171 65 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Jacobsen, Sten Eirik W" sort="Jacobsen, Sten Eirik W" uniqKey="Jacobsen S" first="Sten Eirik W" last="Jacobsen">Sten Eirik W. Jacobsen</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address: sten.jacobsen@imm.ox.ac.uk.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24835589</idno><idno type="pmid">24835589</idno><idno type="doi">10.1016/j.ccr.2014.03.036</idno><idno type="wicri:Area/PubMed/Corpus">003703</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003703</idno><idno type="wicri:Area/PubMed/Curation">003589</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003589</idno><idno type="wicri:Area/PubMed/Checkpoint">003589</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003589</idno><idno type="wicri:Area/Ncbi/Merge">001A39</idno><idno type="wicri:Area/Ncbi/Curation">001A39</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A39</idno><idno type="wicri:Area/Main/Merge">003718</idno><idno type="wicri:Area/Main/Curation">003695</idno><idno type="wicri:Area/Main/Exploration">003695</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.</title><author><name sortKey="Woll, Petter S" sort="Woll, Petter S" uniqKey="Woll P" first="Petter S" last="Woll">Petter S. Woll</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kj Llquist, Una" sort="Kj Llquist, Una" uniqKey="Kj Llquist U" first="Una" last="Kj Llquist">Una Kj Llquist</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm</wicri:regionArea><wicri:noRegion>171 65 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Chowdhury, Onima" sort="Chowdhury, Onima" uniqKey="Chowdhury O" first="Onima" last="Chowdhury">Onima Chowdhury</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Doolittle, Helen" sort="Doolittle, Helen" uniqKey="Doolittle H" first="Helen" last="Doolittle">Helen Doolittle</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Wedge, David C" sort="Wedge, David C" uniqKey="Wedge D" first="David C" last="Wedge">David C. Wedge</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge</wicri:regionArea><wicri:noRegion>CB10 1SA Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Thongjuea, Supat" sort="Thongjuea, Supat" uniqKey="Thongjuea S" first="Supat" last="Thongjuea">Supat Thongjuea</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Erlandsson, Rikard" sort="Erlandsson, Rikard" uniqKey="Erlandsson R" first="Rikard" last="Erlandsson">Rikard Erlandsson</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm</wicri:regionArea><wicri:noRegion>171 65 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Ngara, Mtakai" sort="Ngara, Mtakai" uniqKey="Ngara M" first="Mtakai" last="Ngara">Mtakai Ngara</name><affiliation wicri:level="1"><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm</wicri:regionArea><wicri:noRegion>171 77 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Kristina" sort="Anderson, Kristina" uniqKey="Anderson K" first="Kristina" last="Anderson">Kristina Anderson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Deng, Qiaolin" sort="Deng, Qiaolin" uniqKey="Deng Q" first="Qiaolin" last="Deng">Qiaolin Deng</name><affiliation wicri:level="1"><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm</wicri:regionArea><wicri:noRegion>171 77 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Mead, Adam J" sort="Mead, Adam J" uniqKey="Mead A" first="Adam J" last="Mead">Adam J. Mead</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Stenson, Laura" sort="Stenson, Laura" uniqKey="Stenson L" first="Laura" last="Stenson">Laura Stenson</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Giustacchini, Alice" sort="Giustacchini, Alice" uniqKey="Giustacchini A" first="Alice" last="Giustacchini">Alice Giustacchini</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Duarte, Sara" sort="Duarte, Sara" uniqKey="Duarte S" first="Sara" last="Duarte">Sara Duarte</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Giannoulatou, Eleni" sort="Giannoulatou, Eleni" uniqKey="Giannoulatou E" first="Eleni" last="Giannoulatou">Eleni Giannoulatou</name><affiliation wicri:level="4"><nlm:affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Taylor, Stephen" sort="Taylor, Stephen" uniqKey="Taylor S" first="Stephen" last="Taylor">Stephen Taylor</name><affiliation wicri:level="4"><nlm:affiliation>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Karimi, Mohsen" sort="Karimi, Mohsen" uniqKey="Karimi M" first="Mohsen" last="Karimi">Mohsen Karimi</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Scharenberg, Christian" sort="Scharenberg, Christian" uniqKey="Scharenberg C" first="Christian" last="Scharenberg">Christian Scharenberg</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Mortera Blanco, Teresa" sort="Mortera Blanco, Teresa" uniqKey="Mortera Blanco T" first="Teresa" last="Mortera-Blanco">Teresa Mortera-Blanco</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Macaulay, Iain C" sort="Macaulay, Iain C" uniqKey="Macaulay I" first="Iain C" last="Macaulay">Iain C. Macaulay</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Clark, Sally Ann" sort="Clark, Sally Ann" uniqKey="Clark S" first="Sally-Ann" last="Clark">Sally-Ann Clark</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Dybedal, Ingunn" sort="Dybedal, Ingunn" uniqKey="Dybedal I" first="Ingunn" last="Dybedal">Ingunn Dybedal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Oslo University Hospital, Rikshospitalet, 0130 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Hematology, Oslo University Hospital, Rikshospitalet, 0130 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Josefsen, Dag" sort="Josefsen, Dag" uniqKey="Josefsen D" first="Dag" last="Josefsen">Dag Josefsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Fenaux, Pierre" sort="Fenaux, Pierre" uniqKey="Fenaux P" first="Pierre" last="Fenaux">Pierre Fenaux</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (AP-HP), Service d'hématologie clinique, 93000 Bobigny, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (AP-HP), Service d'hématologie clinique, 93000 Bobigny</wicri:regionArea><wicri:noRegion>93000 Bobigny</wicri:noRegion><wicri:noRegion>93000 Bobigny</wicri:noRegion></affiliation></author><author><name sortKey="Hokland, Peter" sort="Hokland, Peter" uniqKey="Hokland P" first="Peter" last="Hokland">Peter Hokland</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Aarhus University Hospital, 8000 Aarhus</wicri:regionArea><wicri:noRegion>8000 Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Holm, Mette S" sort="Holm, Mette S" uniqKey="Holm M" first="Mette S" last="Holm">Mette S. Holm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Aarhus University Hospital, 8000 Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Aarhus University Hospital, 8000 Aarhus</wicri:regionArea><wicri:noRegion>8000 Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Cazzola, Mario" sort="Cazzola, Mario" uniqKey="Cazzola M" first="Mario" last="Cazzola">Mario Cazzola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Malcovati, Luca" sort="Malcovati, Luca" uniqKey="Malcovati L" first="Luca" last="Malcovati">Luca Malcovati</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Tauro, Sudhir" sort="Tauro, Sudhir" uniqKey="Tauro S" first="Sudhir" last="Tauro">Sudhir Tauro</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Sciences, University of Dundee, Dundee DD1 9SY, Scotland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Medical Sciences, University of Dundee, Dundee DD1 9SY, Scotland</wicri:regionArea><wicri:noRegion>Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Bowen, David" sort="Bowen, David" uniqKey="Bowen D" first="David" last="Bowen">David Bowen</name><affiliation wicri:level="1"><nlm:affiliation>St. James Institute of Oncology, St. James Hospital, Leeds LS9 7TF, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St. James Institute of Oncology, St. James Hospital, Leeds LS9 7TF</wicri:regionArea><wicri:noRegion>Leeds LS9 7TF</wicri:noRegion></affiliation></author><author><name sortKey="Boultwood, Jacqueline" sort="Boultwood, Jacqueline" uniqKey="Boultwood J" first="Jacqueline" last="Boultwood">Jacqueline Boultwood</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Pellagatti, Andrea" sort="Pellagatti, Andrea" uniqKey="Pellagatti A" first="Andrea" last="Pellagatti">Andrea Pellagatti</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Pimanda, John E" sort="Pimanda, John E" uniqKey="Pimanda J" first="John E" last="Pimanda">John E. Pimanda</name><affiliation wicri:level="1"><nlm:affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Unnikrishnan, Ashwin" sort="Unnikrishnan, Ashwin" uniqKey="Unnikrishnan A" first="Ashwin" last="Unnikrishnan">Ashwin Unnikrishnan</name><affiliation wicri:level="1"><nlm:affiliation>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney 2052</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Vyas, Paresh" sort="Vyas, Paresh" uniqKey="Vyas P" first="Paresh" last="Vyas">Paresh Vyas</name><affiliation wicri:level="4"><nlm:affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Oxford University Hospital, NHS Trust, Oxford OX3 9DU, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Oxford University Hospital, NHS Trust, Oxford OX3 9DU</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Gohring, Gudrun" sort="Gohring, Gudrun" uniqKey="Gohring G" first="Gudrun" last="Göhring">Gudrun Göhring</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Schlegelberger, Brigitte" sort="Schlegelberger, Brigitte" uniqKey="Schlegelberger B" first="Brigitte" last="Schlegelberger">Brigitte Schlegelberger</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Cell and Molecular Pathology, Hannover Medical School, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Tobiasson, Magnus" sort="Tobiasson, Magnus" uniqKey="Tobiasson M" first="Magnus" last="Tobiasson">Magnus Tobiasson</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Kvalheim, Gunnar" sort="Kvalheim, Gunnar" uniqKey="Kvalheim G" first="Gunnar" last="Kvalheim">Gunnar Kvalheim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cellular Therapy, Norwegian Radium Hospital, Oslo University Hospital, 0130 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Constantinescu, Stefan N" sort="Constantinescu, Stefan N" uniqKey="Constantinescu S" first="Stefan N" last="Constantinescu">Stefan N. Constantinescu</name><affiliation wicri:level="4"><nlm:affiliation>Ludwig Institute for Cancer Research and de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ludwig Institute for Cancer Research and de Duve Institute, Université Catholique de Louvain, 1200 Brussels</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement><settlement type="city">Louvain-la-Neuve</settlement></placeName><orgName type="university">Université catholique de Louvain</orgName></affiliation></author><author><name sortKey="Nerlov, Claus" sort="Nerlov, Claus" uniqKey="Nerlov C" first="Claus" last="Nerlov">Claus Nerlov</name><affiliation wicri:level="4"><nlm:affiliation>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Molecular Haematology Unit, Department of Haematology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Nilsson, Lars" sort="Nilsson, Lars" uniqKey="Nilsson L" first="Lars" last="Nilsson">Lars Nilsson</name><affiliation wicri:level="1"><nlm:affiliation>Skåne University Hospital, Lund 221 00, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Skåne University Hospital, Lund 221 00</wicri:regionArea><wicri:noRegion>Lund 221 00</wicri:noRegion></affiliation></author><author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge</wicri:regionArea><wicri:noRegion>CB10 1SA Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Sandberg, Rickard" sort="Sandberg, Rickard" uniqKey="Sandberg R" first="Rickard" last="Sandberg">Rickard Sandberg</name><affiliation wicri:level="1"><nlm:affiliation>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm</wicri:regionArea><wicri:noRegion>171 77 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA Cambridge</wicri:regionArea><wicri:noRegion>CB10 1SA Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellström-Lindberg">Eva Hellström-Lindberg</name><affiliation wicri:level="1"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><wicri:noRegion>141 86 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Linnarsson, Sten" sort="Linnarsson, Sten" uniqKey="Linnarsson S" first="Sten" last="Linnarsson">Sten Linnarsson</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 65 Stockholm</wicri:regionArea><wicri:noRegion>171 65 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Jacobsen, Sten Eirik W" sort="Jacobsen, Sten Eirik W" uniqKey="Jacobsen S" first="Sten Eirik W" last="Jacobsen">Sten Eirik W. Jacobsen</name><affiliation wicri:level="4"><nlm:affiliation>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address: sten.jacobsen@imm.ox.ac.uk.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="eISSN">1878-3686</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, CD (biosynthesis)</term><term>Antigens, CD (immunology)</term><term>Chromosome Deletion</term><term>Chromosomes, Human, Pair 5</term><term>Flow Cytometry</term><term>Gene Expression Profiling</term><term>Genetic Predisposition to Disease</term><term>Heterografts</term><term>Humans</term><term>Mice</term><term>Mice, Inbred NOD</term><term>Mutation</term><term>Myelodysplastic Syndromes (genetics)</term><term>Myelodysplastic Syndromes (immunology)</term><term>Myelodysplastic Syndromes (pathology)</term><term>Neoplastic Stem Cells (immunology)</term><term>Neoplastic Stem Cells (pathology)</term><term>Neoplastic Stem Cells (physiology)</term><term>Prognosis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Antigènes CD (biosynthèse)</term><term>Antigènes CD (immunologie)</term><term>Cellules souches tumorales (anatomopathologie)</term><term>Cellules souches tumorales (immunologie)</term><term>Cellules souches tumorales (physiologie)</term><term>Chromosomes humains de la paire 5</term><term>Cytométrie en flux</term><term>Délétion de segment de chromosome</term><term>Humains</term><term>Hétérogreffes</term><term>Mutation</term><term>Pronostic</term><term>Prédisposition génétique à une maladie</term><term>Souris</term><term>Souris de lignée NOD</term><term>Syndromes myélodysplasiques (anatomopathologie)</term><term>Syndromes myélodysplasiques (génétique)</term><term>Syndromes myélodysplasiques (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antigens, CD</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules souches tumorales</term><term>Syndromes myélodysplasiques</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Antigènes CD</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Myelodysplastic Syndromes</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Syndromes myélodysplasiques</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD</term><term>Cellules souches tumorales</term><term>Syndromes myélodysplasiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Myelodysplastic Syndromes</term><term>Neoplastic Stem Cells</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Myelodysplastic Syndromes</term><term>Neoplastic Stem Cells</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules souches tumorales</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neoplastic Stem Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromosome Deletion</term><term>Chromosomes, Human, Pair 5</term><term>Flow Cytometry</term><term>Gene Expression Profiling</term><term>Genetic Predisposition to Disease</term><term>Heterografts</term><term>Humans</term><term>Mice</term><term>Mice, Inbred NOD</term><term>Mutation</term><term>Prognosis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Chromosomes humains de la paire 5</term><term>Cytométrie en flux</term><term>Délétion de segment de chromosome</term><term>Humains</term><term>Hétérogreffes</term><term>Mutation</term><term>Pronostic</term><term>Prédisposition génétique à une maladie</term><term>Souris</term><term>Souris de lignée NOD</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Danemark</li><li>France</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Basse-Saxe</li><li>Nouvelle-Galles du Sud</li><li>Oxfordshire</li><li>Vienne (Autriche)</li><li>Østlandet</li></region><settlement><li>Hanovre</li><li>Louvain-la-Neuve</li><li>Oslo</li><li>Oxford</li><li>Sydney</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université catholique de Louvain</li><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Woll, Petter S" sort="Woll, Petter S" uniqKey="Woll P" first="Petter S" last="Woll">Petter S. Woll</name></region><name sortKey="Boultwood, Jacqueline" sort="Boultwood, Jacqueline" uniqKey="Boultwood J" first="Jacqueline" last="Boultwood">Jacqueline Boultwood</name><name sortKey="Bowen, David" sort="Bowen, David" uniqKey="Bowen D" first="David" last="Bowen">David Bowen</name><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name><name sortKey="Chowdhury, Onima" sort="Chowdhury, Onima" uniqKey="Chowdhury O" first="Onima" last="Chowdhury">Onima Chowdhury</name><name sortKey="Clark, Sally Ann" sort="Clark, Sally Ann" uniqKey="Clark S" first="Sally-Ann" last="Clark">Sally-Ann Clark</name><name sortKey="Doolittle, Helen" sort="Doolittle, Helen" uniqKey="Doolittle H" first="Helen" last="Doolittle">Helen Doolittle</name><name sortKey="Duarte, Sara" sort="Duarte, Sara" uniqKey="Duarte S" first="Sara" last="Duarte">Sara Duarte</name><name sortKey="Giannoulatou, Eleni" sort="Giannoulatou, Eleni" uniqKey="Giannoulatou E" first="Eleni" last="Giannoulatou">Eleni Giannoulatou</name><name sortKey="Giustacchini, Alice" sort="Giustacchini, Alice" uniqKey="Giustacchini A" first="Alice" last="Giustacchini">Alice Giustacchini</name><name sortKey="Macaulay, Iain C" sort="Macaulay, Iain C" uniqKey="Macaulay I" first="Iain C" last="Macaulay">Iain C. Macaulay</name><name sortKey="Mead, Adam J" sort="Mead, Adam J" uniqKey="Mead A" first="Adam J" last="Mead">Adam J. Mead</name><name sortKey="Nerlov, Claus" sort="Nerlov, Claus" uniqKey="Nerlov C" first="Claus" last="Nerlov">Claus Nerlov</name><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name><name sortKey="Pellagatti, Andrea" sort="Pellagatti, Andrea" uniqKey="Pellagatti A" first="Andrea" last="Pellagatti">Andrea Pellagatti</name><name sortKey="Stenson, Laura" sort="Stenson, Laura" uniqKey="Stenson L" first="Laura" last="Stenson">Laura Stenson</name><name sortKey="Tauro, Sudhir" sort="Tauro, Sudhir" uniqKey="Tauro S" first="Sudhir" last="Tauro">Sudhir Tauro</name><name sortKey="Taylor, Stephen" sort="Taylor, Stephen" uniqKey="Taylor S" first="Stephen" last="Taylor">Stephen Taylor</name><name sortKey="Thongjuea, Supat" sort="Thongjuea, Supat" uniqKey="Thongjuea S" first="Supat" last="Thongjuea">Supat Thongjuea</name><name sortKey="Vyas, Paresh" sort="Vyas, Paresh" uniqKey="Vyas P" first="Paresh" last="Vyas">Paresh Vyas</name><name sortKey="Wedge, David C" sort="Wedge, David C" uniqKey="Wedge D" first="David C" last="Wedge">David C. Wedge</name></country><country name="Suède"><noRegion><name sortKey="Kj Llquist, Una" sort="Kj Llquist, Una" uniqKey="Kj Llquist U" first="Una" last="Kj Llquist">Una Kj Llquist</name></noRegion><name sortKey="Deng, Qiaolin" sort="Deng, Qiaolin" uniqKey="Deng Q" first="Qiaolin" last="Deng">Qiaolin Deng</name><name sortKey="Erlandsson, Rikard" sort="Erlandsson, Rikard" uniqKey="Erlandsson R" first="Rikard" last="Erlandsson">Rikard Erlandsson</name><name sortKey="Hellstrom Lindberg, Eva" sort="Hellstrom Lindberg, Eva" uniqKey="Hellstrom Lindberg E" first="Eva" last="Hellström-Lindberg">Eva Hellström-Lindberg</name><name sortKey="Jacobsen, Sten Eirik W" sort="Jacobsen, Sten Eirik W" uniqKey="Jacobsen S" first="Sten Eirik W" last="Jacobsen">Sten Eirik W. Jacobsen</name><name sortKey="Karimi, Mohsen" sort="Karimi, Mohsen" uniqKey="Karimi M" first="Mohsen" last="Karimi">Mohsen Karimi</name><name sortKey="Linnarsson, Sten" sort="Linnarsson, Sten" uniqKey="Linnarsson S" first="Sten" last="Linnarsson">Sten Linnarsson</name><name sortKey="Mortera Blanco, Teresa" sort="Mortera Blanco, Teresa" uniqKey="Mortera Blanco T" first="Teresa" last="Mortera-Blanco">Teresa Mortera-Blanco</name><name sortKey="Ngara, Mtakai" sort="Ngara, Mtakai" uniqKey="Ngara M" first="Mtakai" last="Ngara">Mtakai Ngara</name><name sortKey="Nilsson, Lars" sort="Nilsson, Lars" uniqKey="Nilsson L" first="Lars" last="Nilsson">Lars Nilsson</name><name sortKey="Sandberg, Rickard" sort="Sandberg, Rickard" uniqKey="Sandberg R" first="Rickard" last="Sandberg">Rickard Sandberg</name><name sortKey="Scharenberg, Christian" sort="Scharenberg, Christian" uniqKey="Scharenberg C" first="Christian" last="Scharenberg">Christian Scharenberg</name><name sortKey="Tobiasson, Magnus" sort="Tobiasson, Magnus" uniqKey="Tobiasson M" first="Magnus" last="Tobiasson">Magnus Tobiasson</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Anderson, Kristina" sort="Anderson, Kristina" uniqKey="Anderson K" first="Kristina" last="Anderson">Kristina Anderson</name></region><name sortKey="Dybedal, Ingunn" sort="Dybedal, Ingunn" uniqKey="Dybedal I" first="Ingunn" last="Dybedal">Ingunn Dybedal</name><name sortKey="Josefsen, Dag" sort="Josefsen, Dag" uniqKey="Josefsen D" first="Dag" last="Josefsen">Dag Josefsen</name><name sortKey="Kvalheim, Gunnar" sort="Kvalheim, Gunnar" uniqKey="Kvalheim G" first="Gunnar" last="Kvalheim">Gunnar Kvalheim</name></country><country name="France"><noRegion><name sortKey="Fenaux, Pierre" sort="Fenaux, Pierre" uniqKey="Fenaux P" first="Pierre" last="Fenaux">Pierre Fenaux</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Hokland, Peter" sort="Hokland, Peter" uniqKey="Hokland P" first="Peter" last="Hokland">Peter Hokland</name></noRegion><name sortKey="Holm, Mette S" sort="Holm, Mette S" uniqKey="Holm M" first="Mette S" last="Holm">Mette S. Holm</name></country><country name="Italie"><noRegion><name sortKey="Cazzola, Mario" sort="Cazzola, Mario" uniqKey="Cazzola M" first="Mario" last="Cazzola">Mario Cazzola</name></noRegion><name sortKey="Malcovati, Luca" sort="Malcovati, Luca" uniqKey="Malcovati L" first="Luca" last="Malcovati">Luca Malcovati</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Pimanda, John E" sort="Pimanda, John E" uniqKey="Pimanda J" first="John E" last="Pimanda">John E. Pimanda</name></region><name sortKey="Unnikrishnan, Ashwin" sort="Unnikrishnan, Ashwin" uniqKey="Unnikrishnan A" first="Ashwin" last="Unnikrishnan">Ashwin Unnikrishnan</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Gohring, Gudrun" sort="Gohring, Gudrun" uniqKey="Gohring G" first="Gudrun" last="Göhring">Gudrun Göhring</name></region><name sortKey="Schlegelberger, Brigitte" sort="Schlegelberger, Brigitte" uniqKey="Schlegelberger B" first="Brigitte" last="Schlegelberger">Brigitte Schlegelberger</name></country><country name="Belgique"><region name="Vienne (Autriche)"><name sortKey="Constantinescu, Stefan N" sort="Constantinescu, Stefan N" uniqKey="Constantinescu S" first="Stefan N" last="Constantinescu">Stefan N. Constantinescu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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